Following moderate to severe traumatic brain injury (msTBI) in children, white matter disruption was widespread, persistent, and impacted by demographic and clinical factors, according to study findings published in Neurology.

Study researchers analyzed data from the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Pediatric msTBI working group collaboration. At 7 sites in 3 countries, 10 cohorts of children and adolescents (n=244) with msTBI and controls (n=263) who were either healthy or had orthopedic injuries were assessed by diffusion magnetic resonance imaging (dMRI) and neurobehavioral instruments.

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